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Al Jinan الجنان

Abstract

Paracetamol is widely used without prescription as an over the counter (OTC) drug. Many studies reported that it causes renal toxicity unlike ACE inhibitors like Captopril that can have renal protective effects. Since many patients may take Paracetamol and Captopril concomitantly, the aim of this study is to evaluate the renal protective effect of Captopril on Paracetamol induced nephrotoxicity. The present study was conducted in two phases. Phase (1): high dose Paracetamol: Animals were divided into 4 groups of 6 rats each. Group 1 (control group), Group 2 (Paracetamol 3000 mg/kg group) and Group 3 (Captopril 20 mg/kg group) were pretreated orally with 0.9 % normal saline consecutively for 7 days; Group 4 (Captopril + Paracetamol group) was pretreated with Captopril 20 mg/kg consecutively for 7 days. After 24 hours (on day 8), group 1 administered 0.9 % normal saline, whereas group 2 (paracetamol) and group 4 (Captopril + Paracetamol) administered single oral dose of Paracetamol 3000 mg/kg; group 3 administered captopril 20 mg/kg. Rats were then sacrificed and the kidneys were dissected for histopathological studies. Phase (2): low dose paracetamol: Rats were divided into 4 groups of 6 rats each. Group 1: was treated orally with 0.9% normal saline, Group 2: received paracetamol (300 mg/kg), Group 3: administered captopril (20 mg/ kg) and Group 4: administered both captopril (20 mg/kg) and pracetamol (300mg/kg) for 10 days consecutively. The animals were then sacrificed and the kidneys were dissected for histopathological studies. Paracetamol in both high and low doses produced nephrotoxic effects while Captopril showed marked protection against damage induced by Paracetamol on the kidney.





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