Dynamics of Zika Virus Model with Nonlinear Incidence and Optimal Control Strategies

Authors

Samson Olaniyi, Department of Pure and Applied Mathematics, Ladoke Akintola University of Technology, PMB 4000 Ogbomoso, NigeriaFollow

Author Country (or Countries)

Nigeria

Abstract

We formulate and analyze Zika virus transmission model with three nonlinear forces of infection from infected mosquito, asymptomatic and symptomatic humans. The sensitivity indexes of the associated parameters of the model with respect to the basic reproduction number are calculated to identify intervention strategies for prevention and control of Zika virus. Multiple time-dependent optimal controls are considered. The analysis based on the use of optimal control theory made popular by Pontryagin’s maximum principle is carried out, and the resulting optimality system is quantitatively simulated to investigate the impact of the controls on the dynamics of Zika virus. In addition, the effects of non-linearity of the forces of infection and other key parameters on the disease transmission are illustrated.

Digital Object Identifier (DOI)

http://dx.doi.org/10.18576/amis/120510

Recommended Citation

Olaniyi, Samson (2018) "Dynamics of Zika Virus Model with Nonlinear Incidence and Optimal Control Strategies," Applied Mathematics & Information Sciences: Vol. 12: Iss. 5, Article 10.
DOI: http://dx.doi.org/10.18576/amis/120510
Available at: https://digitalcommons.aaru.edu.jo/amis/vol12/iss5/10