International Arab Journal of Dentistry
DOI
https://doi.org/10.70174/iajd.v16i1.1405
Abstract
Langerhans Cell Histiocytosis (LCH) is a rare disease characterized by the abnormal proliferation of Langerhans cells. It has a wide clinical spectrum, ranging from single system to multisystem involvement, and frequently affects children, although cases in adults have been reported. Oral manifestations of LCH are non-specific and may mimic common periodontal conditions, posing a diagnostic challenge for dental practitioners. A 63-year-old female patient presented to the Saint Joseph's University Dental Care Center in Beirut with complaints of periodontal problems. She was first diagnosed with periodontitis. Despite treatment, symptoms persisted, prompting a referral for further evaluation. Histopathological analysis, supported by immunohistochemistry (CD1a and S100 positivity), confirmed the diagnosis of LCH and she was treated with systemic chemotherapy. LCH is a rare yet important differential diagnosis for patients presenting with persistent oral lesions, requiring a multidisciplinary approach for definitive diagnosis. Early recognition and treatment of LCH can prevent disease progression and complications.
Recommended Citation
AL MANHAL, Wassim; saad, georgio; Anka, Charbel; aftimos, Valerie; daccache, michael; abi raad, sophie; and boujaoude, georges
(2025)
"Oral Lesion as the Initial Presentation in the Diagnosis of Histiocytosis X: A Case Report with 16-month follow-up,"
International Arab Journal of Dentistry: Vol. 16:
Iss.
1, Article 18.
DOI: https://doi.org/10.70174/iajd.v16i1.1405
Available at:
https://digitalcommons.aaru.edu.jo/iajd/vol16/iss1/18