Zagazig University Medical Journal


Background: The relationship between inflammation and psychiatric disorders has been widely debated. Psychiatric patients had features of inflammation, such as high levels of inflammatory markers. This study was conducted to assess plasma C-reactive protein level (CRP) in patients with major depressive disorder (MDD) and compare them with healthy controls.Methods: A sample of 196 participants (98 cases, 98 controls) was taken, cases satisfied the diagnosis of MDD according to Diagnostic and statistical manual of mental disorder (DSM-5). Blood samples were collected from patients and controls to measure plasma levels of CRP. Severity of depression in patients was assessed by Beck depression inventory and the Hamilton depression rating scale. Results: There was a statistically significant elevation of CRP levels in patients with MDD compared to control group with P value 0.009. Also there was a significant correlation between CRP level and degree of severity of depression.Conclusion: CRP was elevated in patients with MDD and associated with severity of MDD. This result supports the previous findings that inflammatory hypothesis has a great role in major depressive disorder pathogenesis.



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