Zagazig University Medical Journal


Objective: To assess the serum level of Semaphorin 3A in ankylosing spondylitis (AS) patients and to assess its correlation with disease activity. Subjects and Methods: The study was carried on 40 subjects, 20 AS patients (12 males and 8 females) fulfilled the 1984 Modified New York criteria for diagnosis of ankylosing spondylitis, and 20 healthy subjects, taken as control group (12 females and 8 males). A consent was taken from all subjects to share in the study. Disease Activity Score (ASDAS) was calculated for AS patients and functional assessment was done using the Bath Ankylosing Spondylitis Functional Index (BASFI). Results: Serum levels of Semaphorin 3A were significantly higher(P



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