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Delta University Scientific Journal

Delta University Scientific Journal

Arabic Title

السمية العصبية والكبدية الناتجة عن كاربوبلاتين وثاليدوميد في الجرذان: التأثير المخفض لمستخلص الحنظل

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Abstract

Carboplatin and thalidomide are good candidate’s treatments against many types of cancer. Latest studies demonstrated that these chemotherapeutic druges caused oxidative damage. So, the present study was conducted to estimate the neurotoxic and hepatotoxic effects induced by carboplatin/ thalidomide regimen and to explore the potential protective effect of Citrillus colocynthis extract (CCE). The obtained results showed that carboplatin/thalidomide induced histological changes, caused significant elevation in serum liver enzymes, decline in brain and plasma neurotransmitters, and increase in acetylcholine esterase. At the molecular level, thalidomide/carboplatin caused marked elevation in inflammatory and apoptotic markers and suppressed the expression of proliferator-activated receptor-gamma coactivator-1 and mitochondrial transcription factor a in brain and liver tissues. Also, the regemin declined the GSH system and nuclear factor erythroid-2-related factor 2 (NRF2), and induced oxidative stress as indicated by elevated tissues level of thiobarbituric acid reactive substances and 8-hydroxydeoxyguanosine. The co-supplemnation with CCE minimized thalidomide/carboplatin-induced abnormalities in brain and liver tissues. As a result, the current findings revealed that CCE may have a protective effect against carboplatin/thalidomide-induced toxicity.

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