International Arab Journal of Dentistry


Objective: The material used for pulp capping has a significant impact on the outcome of vital pulp therapy. This study compared the pulp tissue response to Pulpine NE versus Biodentine as direct pulp capping materials in a dog model.

Methods: Twenty-four teeth in two mongrel dogs (1-2-year-old) were used. In each dog (n=12 teeth), the dental pulps were exposed in 8 teeth (2 experimental groups, 4 teeth each) and left unexposed in 4 teeth (control group, n=4 teeth). A class V cavity was performed on the buccal surface of the selected teeth in the experimental groups. The exposed pulps were capped either with Pulpine-NE (group I) or Biodentine (group II). Then, the cavities were restored with Riva resin modified glass ionomer filling material. One dog was euthanized at 14 days after pulp capping and the second dog was euthanized after 45 days. Histological analysis of the continuity of dentin bridge, tissue disorganization and inflammatory reaction were statistically analyzed.

Results: The results revealed that Biodentine exhibited statistically significant higher dentin bridge formation than Pulpine NE after 14 and 45 days (PConclusion: Pulpine NE was capable of inducing reparative dentin when used as a direct pulp capping material. Nevertheless, Biodentine showed more efficient dentin bridge formation, tissue organization and anti-inflammatory potential than Pulpine NE.